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DOI: https://doi.org/10.63345/ijrsml.v12.i7.1
Krithika. V
Research Scholar
Maharaja Agrasen Himalayan Garhwal University
Uttarakhand, India
Dr. Sarbesh Kumar Singh
Research Guide
Maharaja Agrasen Himalayan Garhwal University
Uttarakhand, India
Abstract— Lifestyle disorders such as obesity, diabetes, irritable bowel syndrome, anxiety, and stress-related metabolic dysfunction are increasingly recognized as multifactorial conditions driven by chronic psychological stress and gut microbial imbalance. Conventional treatment models often address symptomatic manifestations while overlooking the interconnected neuropsychological and gastrointestinal mechanisms underlying disease persistence and relapse. This study explores psychological stress modulation and gut microbial rebalancing as dual, synergistic pathways for achieving sustainable recovery from lifestyle disorders. The research adopts an integrative framework combining structured psychological interventions—such as stress regulation strategies, cognitive behavioral techniques, and lifestyle counseling—with gut-focused therapeutic approaches including dietary modulation, prebiotic-probiotic support, and microbiome-friendly behavioral practices. Quantitative health indicators (body mass index, glycemic markers, sleep quality, and digestive regularity) are assessed alongside qualitative measures such as emotional regulation, perceived stress, energy levels, and treatment adherence. Findings indicate that stress reduction significantly enhances gut microbial stability by improving vagal tone, hormonal balance, and immune regulation, while microbial rebalancing positively influences mood, cognitive clarity, and stress resilience through the gut–brain axis. The dual-pathway approach demonstrates superior long-term outcomes compared to isolated interventions, reducing symptom recurrence and promoting behavioral sustainability. This study underscores the necessity of integrated mind–gut therapeutic models in addressing lifestyle disorders and contributes to the development of holistic, resilience-oriented healthcare strategies.
Keywords— Psychological stress modulation; Gut microbiome rebalancing; Lifestyle disorder recovery; Gut–brain axis; Stress resilience; Microbial diversity
References
- Adler, N. E., & Stewart, J. (2010). Health disparities across the lifespan: Meaning, methods, and mechanisms. Annals of the New York Academy of Sciences, 1186(1), 5–23.
- Bauer, M. E., & Teixeira, A. L. (2019). Inflammation in psychiatric disorders: What comes first? Annals of the New York Academy of Sciences, 1437(1), 57–67.
- Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13(10), 701–712.
- Foster, J. A., Rinaman, L., & Cryan, J. F. (2017). Stress and the gut–brain axis: Regulation by the microbiome. Neurobiology of Stress, 7, 124–136.
- Liu, R. T. (2017). The microbiome as a novel paradigm in studying stress and mental health. American Psychologist, 72(7), 655–667.
- McEwen, B. S. (2007). Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiological Reviews, 87(3), 873–904.
- Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014). Gut microbes and the brain: Paradigm shift in neuroscience. The Journal of Neuroscience, 34(46), 15490–15496.
- O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015). Serotonin, tryptophan metabolism and the brain–gut–microbiome axis. Behavioural Brain Research, 277, 32–48.
- Sapolsky, R. M. (2015). Why zebras don’t get ulcers (3rd ed.). New York, NY: Henry Holt and Company.
- Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018). Recent developments in understanding the role of the gut microbiota in brain health and disease. Annals of the New York Academy of Sciences, 1420(1), 5–25.